Local dark matter searches with LISA

The drag-free satellites of LISA will maintain the test masses in geodesic motion over many years with residual accelerations at unprecedented small levels and time delay interferometry (TDI) will keep track of their differential positions at level of picometers. This may allow investigations of fine details of the gravitational field in the Solar System previously inaccessible. In this spirit, we present the concept of a method to measure directly the gravitational effect of the density of diffuse Local Dark Matter (LDM) with a constellation of a few drag-free satellites, by exploiting how peculiarly it would affect their relative motion. Using as test bed an idealized LISA with rigid arms, we find that the separation in time between the test masses is uniquely perturbed by the LDM, so that they acquire a differential breathing mode. Such a LDM signal is related to the LDM density within the orbits and has characteristic spectral components, with amplitudes increasing in time, at various frequencies of the dynamics of the constellation. This is the relevant result, in that the LDM signal is brought to non-zero frequencies.Comment: 8 pages, 1 figure; v2: minor changes to match the version in press on Classical and Quantum Gravity (special issue for the 7th International LISA Symposium proceedings

Supersymmetry Relations Between Contributions To One-Loop Gauge Boson Amplitudes

We apply ideas motivated by string theory to improve the calculational efficiency of one-loop weak interaction processes with massive external gauge bosons. In certain cases ``supersymmetry'' relations between diagrams with a fermion loop and with a gauge boson loop hold. This is explicitly illustrated for a particular one-loop standard model process with four-external gauge bosons. The supersymmetry relations can be used to provide further significant improvements in calculational efficiency.Comment: 21 pages of plain TeX + 5 PostScript figures (compressed and uuencoded), UCLA/93/TEP/36 and DTP/93/8

The stellar halo of the Galaxy

Stellar halos may hold some of the best preserved fossils of the formation history of galaxies. They are a natural product of the merging processes that probably take place during the assembly of a galaxy, and hence may well be the most ubiquitous component of galaxies, independently of their Hubble type. This review focuses on our current understanding of the spatial structure, the kinematics and chemistry of halo stars in the Milky Way. In recent years, we have experienced a change in paradigm thanks to the discovery of large amounts of substructure, especially in the outer halo. I discuss the implications of the currently available observational constraints and fold them into several possible formation scenarios. Unraveling the formation of the Galactic halo will be possible in the near future through a combination of large wide field photometric and spectroscopic surveys, and especially in the era of Gaia.Comment: 46 pages, 16 figures. References updated and some minor changes. Full-resolution version available at http://www.astro.rug.nl/~ahelmi/stellar-halo-review.pd

Chromosomal-level assembly of the Asian Seabass genome using long sequence reads and multi-layered scaffolding

We report here the ~670 Mb genome assembly of the Asian seabass (Lates calcarifer), a tropical marine teleost. We used long-read sequencing augmented by transcriptomics, optical and genetic mapping along with shared synteny from closely related fish species to derive a chromosome-level assembly with a contig N50 size over 1 Mb and scaffold N50 size over 25 Mb that span ~90% of the genome. The population structure of L. calcarifer species complex was analyzed by re-sequencing 61 individuals representing various regions across the species' native range. SNP analyses identified high levels of genetic diversity and confirmed earlier indications of a population stratification comprising three clades with signs of admixture apparent in the South-East Asian population. The quality of the Asian seabass genome assembly far exceeds that of any other fish species, and will serve as a new standard for fish genomics

CADM1 inhibits squamous cell carcinoma progression by reducing STAT3 activity.

Although squamous cell carcinomas (SqCCs) of the lungs, head and neck, oesophagus, and cervix account for up to 30% of cancer deaths, the mechanisms that regulate disease progression remain incompletely understood. Here, we use gene transduction and human tumor xenograft assays to establish that the tumour suppressor Cell adhesion molecule 1 (CADM1) inhibits SqCC proliferation and invasion, processes fundamental to disease progression. We determine that the extracellular domain of CADM1 mediates these effects by forming a complex with HER2 and integrin α6β4 at the cell surface that disrupts downstream STAT3 activity. We subsequently show that treating CADM1 null tumours with the JAK/STAT inhibitor ruxolitinib mimics CADM1 gene restoration in preventing SqCC growth and metastases. Overall, this study identifies a novel mechanism by which CADM1 prevents SqCC progression and suggests that screening tumours for loss of CADM1 expression will help identify those patients most likely to benefit from JAK/STAT targeted chemotherapies